Dr. Somani's research interests included Biochemical Pharmacology, Toxicology, Antibiotics, and Anti-cancer agents.

Somani's teaching material at SIU included: Antibiotics, Pharmacokinetics of Antibiotics, Antifungal, Anti-malarial, Antiviral, Antibacterial, Anti-parasitic Agents, Cancer Chemotherapeutic Agents, Toxicology, Drug-Drug Interactions, Adverse Drug Reactions, Anti-coagulants, Anti-anemics, Radioisotopes as Drugs and Diagnostic Aids, and other biochemical pharmacology related Topics.